recipe bioconductor-tloh

Assessment of evidence for LOH in spatial transcriptomics pre-processed data using Bayes factor calculations

Homepage:

https://bioconductor.org/packages/3.16/bioc/html/tLOH.html

License:

MIT + file LICENSE

Recipe:

/bioconductor-tloh/meta.yaml

tLOH, or transcriptomicsLOH, assesses evidence for loss of heterozygosity (LOH) in pre-processed spatial transcriptomics data. This tool requires spatial transcriptomics cluster and allele count information at likely heterozygous single-nucleotide polymorphism (SNP) positions in VCF format. Bayes factors are calculated at each SNP to determine likelihood of potential loss of heterozygosity event. Two plotting functions are included to visualize allele fraction and aggregated Bayes factor per chromosome. Data generated with the 10X Genomics Visium Spatial Gene Expression platform must be pre-processed to obtain an individual sample VCF with columns for each cluster. Required fields are allele depth (AD) with counts for reference/alternative alleles and read depth (DP).

package bioconductor-tloh

Versions:

1.6.0-0,  1.2.0-0,  1.0.0-0

Depends:

• bioconductor-genomicranges >=1.50.0,<1.51.0

• bioconductor-matrixgenerics >=1.10.0,<1.11.0

• bioconductor-variantannotation >=1.44.0,<1.45.0

• r-base >=4.2,<4.3.0a0

• r-bestnormalize

• r-data.table

• r-depmixs4

• r-dplyr

• r-ggplot2

• r-naniar

• r-purrr

• r-scales

• r-stringr

Required By:

Installation

With an activated Bioconda channel (see set-up-channels), install with:

conda install bioconductor-tloh

and update with:

conda update bioconductor-tloh

or use the docker container:

docker pull quay.io/biocontainers/bioconductor-tloh:<tag>

(see bioconductor-tloh/tags for valid values for <tag>)

Download stats

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