ChExAlign is used for alignment and quantification of ChIP-exo crosslinking patterns.
ChExAlign is a computational framework that aligns ChIP-exo crosslinking patterns from multiple proteins across a set of regulatory regions, and which detects and quantifies protein-DNA crosslinking events within the aligned profiles. The output of the alignment approach is a set of composite profiles that represent the crosslinking signatures of the complex across analyzed regulatory regions. We then use a probabilistic mixture model to deconvolve individual crosslinking events within the aligned ChIP-exo profiles, enabling consistent measurements of protein-DNA crosslinking strengths across multiple proteins.
- Required By
With an activated Bioconda channel (see 2. Set up channels), install with:
conda install chexalign
and update with:
conda update chexalign
or use the docker container:
docker pull quay.io/biocontainers/chexalign:<tag>
(see chexalign/tags for valid values for