recipe bioconductor-aldex2

Analysis Of Differential Abundance Taking Sample and Scale Variation Into Account



GPL (>=3)




biotools: aldex2

A differential abundance analysis for the comparison of two or more conditions. Useful for analyzing data from standard RNA-seq or meta-RNA-seq assays as well as selected and unselected values from in-vitro sequence selections. Uses a Dirichlet-multinomial model to infer abundance from counts, optimized for three or more experimental replicates. The method infers biological and sampling variation to calculate the expected false discovery rate, given the variation, based on a Wilcoxon Rank Sum test and Welch's t-test (via aldex.ttest), a Kruskal-Wallis test (via, a generalized linear model (via aldex.glm), or a correlation test (via aldex.corr). All tests report predicted p-values and posterior Benjamini-Hochberg corrected p-values. ALDEx2 also calculates expected standardized effect sizes for paired or unpaired study designs. ALDEx2 can now be used to estimate the effect of scale on the results and report on the scale-dependent robustness of results.

package bioconductor-aldex2

(downloads) docker_bioconductor-aldex2



depends bioconductor-biocparallel:


depends bioconductor-genomicranges:


depends bioconductor-iranges:


depends bioconductor-multtest:


depends bioconductor-s4vectors:


depends bioconductor-summarizedexperiment:


depends r-base:


depends r-directlabels:

depends r-lattice:

depends r-latticeextra:

depends r-rfast:

depends r-zcompositions:



You need a conda-compatible package manager (currently either micromamba, mamba, or conda) and the Bioconda channel already activated (see set-up-channels).

While any of above package managers is fine, it is currently recommended to use either micromamba or mamba (see here for installation instructions). We will show all commands using mamba below, but the arguments are the same for the two others.

Given that you already have a conda environment in which you want to have this package, install with:

   mamba install bioconductor-aldex2

and update with::

   mamba update bioconductor-aldex2

To create a new environment, run:

mamba create --name myenvname bioconductor-aldex2

with myenvname being a reasonable name for the environment (see e.g. the mamba docs for details and further options).

Alternatively, use the docker container:

   docker pull<tag>

(see `bioconductor-aldex2/tags`_ for valid values for ``<tag>``)

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