recipe bioconductor-decoupler

Package to decouple gene sets from statistics






Transcriptome profiling followed by differential gene expression analysis often leads to lists of genes that are hard to analyze and interpret. Downstream analysis tools can be used to summarize deregulation events into a smaller set of biologically interpretable features. In particular, methods that estimate the activity of transcription factors (TFs) from gene expression are commonly used. It has been shown that the transcriptional targets of a TF yield a much more robust estimation of the TF activity than observing the expression of the TF itself. Consequently, for the estimation of transcription factor activities, a network of transcriptional regulation is required in combination with a statistical algorithm that summarizes the expression of the target genes into a single activity score. Over the years, many different regulatory networks and statistical algorithms have been developed, mostly in a fixed combination of one network and one algorithm. To systematically evaluate both networks and algorithms, we developed decoupleR , an R package that allows users to apply efficiently any combination provided.

package bioconductor-decoupler

(downloads) docker_bioconductor-decoupler



Required By


With an activated Bioconda channel (see 2. Set up channels), install with:

conda install bioconductor-decoupler

and update with:

conda update bioconductor-decoupler

or use the docker container:

docker pull<tag>

(see bioconductor-decoupler/tags for valid values for <tag>)

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