recipe bioconductor-ifaa

Robust Inference for Absolute Abundance in Microbiome Analysis






This package offers a robust approach to make inference on the association of covariates with the absolute abundance (AA) of microbiome in an ecosystem. It can be also directly applied to relative abundance (RA) data to make inference on AA because the ratio of two RA is equal to the ratio of their AA. This algorithm can estimate and test the associations of interest while adjusting for potential confounders. The estimates of this method have easy interpretation like a typical regression analysis. High-dimensional covariates are handled with regularization and it is implemented by parallel computing. False discovery rate is automatically controlled by this approach. Zeros do not need to be imputed by a positive value for the analysis. The IFAA package also offers the 'MZILN' function for estimating and testing associations of abundance ratios with covariates.

package bioconductor-ifaa

(downloads) docker_bioconductor-ifaa



depends bioconductor-s4vectors:


depends bioconductor-summarizedexperiment:


depends r-base:


depends r-desctools:

depends r-doparallel:


depends r-dorng:

depends r-foreach:


depends r-glmnet:

depends r-hdci:


depends r-mathjaxr:

depends r-matrix:


depends r-matrixextra:

depends r-parallelly:

depends r-stringr:



You need a conda-compatible package manager (currently either micromamba, mamba, or conda) and the Bioconda channel already activated (see set-up-channels).

While any of above package managers is fine, it is currently recommended to use either micromamba or mamba (see here for installation instructions). We will show all commands using mamba below, but the arguments are the same for the two others.

Given that you already have a conda environment in which you want to have this package, install with:

   mamba install bioconductor-ifaa

and update with::

   mamba update bioconductor-ifaa

To create a new environment, run:

mamba create --name myenvname bioconductor-ifaa

with myenvname being a reasonable name for the environment (see e.g. the mamba docs for details and further options).

Alternatively, use the docker container:

   docker pull<tag>

(see `bioconductor-ifaa/tags`_ for valid values for ``<tag>``)

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