recipe bioconductor-scmet

Bayesian modelling of cell-to-cell DNA methylation heterogeneity






High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task. scMET is a hierarchical Bayesian model which overcomes sparsity, sharing information across cells and genomic features to robustly quantify genuine biological heterogeneity. scMET can identify highly variable features that drive epigenetic heterogeneity, and perform differential methylation and variability analyses. We illustrate how scMET facilitates the characterization of epigenetically distinct cell populations and how it enables the formulation of novel hypotheses on the epigenetic regulation of gene expression.

package bioconductor-scmet

(downloads) docker_bioconductor-scmet



depends bioconductor-biocstyle:


depends bioconductor-biocstyle:


depends bioconductor-s4vectors:


depends bioconductor-s4vectors:


depends bioconductor-singlecellexperiment:


depends bioconductor-singlecellexperiment:


depends bioconductor-summarizedexperiment:


depends bioconductor-summarizedexperiment:


depends libblas:


depends libgcc-ng:


depends liblapack:


depends libstdcxx-ng:


depends r-assertthat:

depends r-base:


depends r-bh:


depends r-coda:

depends r-cowplot:

depends r-data.table:

depends r-dplyr:

depends r-ggplot2:

depends r-logitnorm:

depends r-mass:

depends r-matrix:

depends r-matrixstats:

depends r-rcpp:


depends r-rcppeigen:


depends r-rcppparallel:


depends r-rstan:


depends r-rstantools:


depends r-stanheaders:


depends r-vgam:

depends r-viridis:



You need a conda-compatible package manager (currently either micromamba, mamba, or conda) and the Bioconda channel already activated (see set-up-channels).

While any of above package managers is fine, it is currently recommended to use either micromamba or mamba (see here for installation instructions). We will show all commands using mamba below, but the arguments are the same for the two others.

Given that you already have a conda environment in which you want to have this package, install with:

   mamba install bioconductor-scmet

and update with::

   mamba update bioconductor-scmet

To create a new environment, run:

mamba create --name myenvname bioconductor-scmet

with myenvname being a reasonable name for the environment (see e.g. the mamba docs for details and further options).

Alternatively, use the docker container:

   docker pull<tag>

(see `bioconductor-scmet/tags`_ for valid values for ``<tag>``)

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