recipe r-mobster

Model-based subclonal deconvolution from bulk sequencing.

Homepage:

https://github.com/caravagnalab/mobster

Documentation:

https://caravagnalab.github.io/mobster/

License:

GPL3 / GPL-3.0-or-later

Recipe:

/r-mobster/meta.yaml

MOBSTER is a package that implements a statistical model for tumour subclonal deconvolution which combines Dirichlet mixtures with distributions predicted by theoretical population genetics. The model implemented is a parametric (finite) mixture with multiple Beta components, and one Pareto power law tail. Beta components capture mutations that rise up in frequency by positive selection, and the Pareto tail models alleles resulting from neutral, intra-clone, evolutionary dynamics.

package r-mobster

(downloads) docker_r-mobster

Versions:

0.1.1-0

Depends:
  • on r-base >=4.4,<4.5.0a0

  • on r-cli

  • on r-clisymbols

  • on r-cowplot

  • on r-crayon

  • on r-dndscv

  • on r-dplyr

  • on r-easypar

  • on r-ggplot2

  • on r-ggpubr

  • on r-ggrepel

  • on r-ggthemes

  • on r-magrittr

  • on r-pio

  • on r-sads

  • on r-tidyr

  • on r-tidyverse

  • on r-vcfr

Additional platforms:

Installation

You need a conda-compatible package manager (currently either pixi, conda, or micromamba) and the Bioconda channel already activated (see Usage). Below, we show how to install with either pixi or conda (for micromamba and mamba, commands are essentially the same as with conda).

Pixi

With pixi installed and the Bioconda channel set up (see Usage), to install globally, run:

pixi global install r-mobster

to add into an existing workspace instead, run:

pixi add r-mobster

In the latter case, make sure to first add bioconda and conda-forge to the channels considered by the workspace:

pixi workspace channel add conda-forge
pixi workspace channel add bioconda

Conda

With conda installed and the Bioconda channel set up (see Usage), to install into an existing and activated environment, run:

conda install r-mobster

Alternatively, to install into a new environment, run:

conda create -n envname r-mobster

with envname being the name of the desired environment.

Container

Alternatively, every Bioconda package is available as a container image for usage with your preferred container runtime. For e.g. docker, run:

docker pull quay.io/biocontainers/r-mobster:<tag>

(see r-mobster/tags for valid values for <tag>).

Integrated deployment

Finally, note that many scientific workflow management systems directly integrate both conda and container based software deployment. Thus, workflow steps can be often directly annotated to use the package, leading to automatic deployment by the respective workflow management system, thereby improving reproducibility and transparency. Check the documentation of your workflow management system to find out about the integration.

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